Analysis of Human Prions to Determine their Potential Functions
Start Date
April 2024
Location
2nd floor - Library
Abstract
Prion proteins are dangerous proteins that have misfolded from the usual shape and function then causing a build up of plaques, or more prions, mostly found in the brain. Through this analysis, a different number of in silico programs are used to potentially determine the function of these dangerous proteins. Programs used include SPRITE, Dali, BLAST, Inter Pro, and Chimera. Through these programs the seven Homo sapiens prion proteins that were chosen to be examined were assigned similar proteins in order to give a putative function. Most prions were assigned the function of a transferase, but with some exceptions such as NAD binding. The comparison was completed by overlapping the prion proteins with the sequences of other similar proteins. Future research can be done to confirm these functions by purifying the protein and testing the kinetics of it.
Analysis of Human Prions to Determine their Potential Functions
2nd floor - Library
Prion proteins are dangerous proteins that have misfolded from the usual shape and function then causing a build up of plaques, or more prions, mostly found in the brain. Through this analysis, a different number of in silico programs are used to potentially determine the function of these dangerous proteins. Programs used include SPRITE, Dali, BLAST, Inter Pro, and Chimera. Through these programs the seven Homo sapiens prion proteins that were chosen to be examined were assigned similar proteins in order to give a putative function. Most prions were assigned the function of a transferase, but with some exceptions such as NAD binding. The comparison was completed by overlapping the prion proteins with the sequences of other similar proteins. Future research can be done to confirm these functions by purifying the protein and testing the kinetics of it.
