Synthesis of B-Arrestin D2 Biased Dopamine Agonist
Start Date
April 2024
Location
2nd floor - Library
Abstract
Aripiprazole is one of the most commonly prescribed antipsychotic drugs on the market that relies on dopamine receptor agonism as the mechanism of action. Derivatives of this compound including 7-(4-(4-(2,3-Dichlorophenyl)-1,4-diazepan-1-yl)butoxy)-3,4-dihydroquinolin-2 (1H)-one, have been studied and found to be a partial agonist of D2-receptor with selectivity for β-Arrestin over cAMP signal pathways. Synthesis of this derivative was selected based on high potency, and therefore need for lower product yield to be utilized for further testing of antipsychotic effects in C. Elegans as model organisms
Synthesis of B-Arrestin D2 Biased Dopamine Agonist
2nd floor - Library
Aripiprazole is one of the most commonly prescribed antipsychotic drugs on the market that relies on dopamine receptor agonism as the mechanism of action. Derivatives of this compound including 7-(4-(4-(2,3-Dichlorophenyl)-1,4-diazepan-1-yl)butoxy)-3,4-dihydroquinolin-2 (1H)-one, have been studied and found to be a partial agonist of D2-receptor with selectivity for β-Arrestin over cAMP signal pathways. Synthesis of this derivative was selected based on high potency, and therefore need for lower product yield to be utilized for further testing of antipsychotic effects in C. Elegans as model organisms
