Ketamine Pharmacokinetics
Start Date
2023 3:20 PM
Location
Alter Hall 302
Abstract
Ketamine is an intricate drug with many indicated uses. These indications grow with more research leading scientists to believe that ketamine can be used not only for anesthesia, but depression, post-traumatic stress disorder. Ketamine is commonly used in hospital systems for comfort care of terminally ill patients which primarily is administered intravenously (IV). Other routes of administration include nasal and rectal insertion. To build the pharmacokinetic model to represent the movement of ketamine through a child and adult, it must be able to consider quantitative as well as qualitative data. Children and adults undergo 1st order absorption where the absorption rate is proportional to the concentration of the drug, with IV administration this is not relevant because it goes directly into the circulatory system. Using MATLAB, a three compartmental model was constructed to determine the clearance of ketamine.
Ketamine Pharmacokinetics
Alter Hall 302
Ketamine is an intricate drug with many indicated uses. These indications grow with more research leading scientists to believe that ketamine can be used not only for anesthesia, but depression, post-traumatic stress disorder. Ketamine is commonly used in hospital systems for comfort care of terminally ill patients which primarily is administered intravenously (IV). Other routes of administration include nasal and rectal insertion. To build the pharmacokinetic model to represent the movement of ketamine through a child and adult, it must be able to consider quantitative as well as qualitative data. Children and adults undergo 1st order absorption where the absorption rate is proportional to the concentration of the drug, with IV administration this is not relevant because it goes directly into the circulatory system. Using MATLAB, a three compartmental model was constructed to determine the clearance of ketamine.
