Dissolutions Role in Drug Development
Start Date
29-4-2022 3:45 PM
Location
Alter Hall Poster Session 2 - 2nd floor
Abstract
The purpose of this research is to understand the process of drug dissolution. Drug dissolution is important since the rate and completeness of the dissolution effect how and if a drug will work. Within this experiment, the dissolution rates of different forms of Aspirin were tested using various pH’s and stir rates. Using a UV-Vis spectrophotometer to test the absorbances of the samples over various time intervals, the maximum release of the drug can be found using calibration and dissolution curves. It was found through the research, that pH and stir rate both affected the dissolution rates of immediate release Aspirin tablets. It was also found that the immediate release has a much quicker dissolution rate than the extended release. Ultimately, from the work done in this research, a lab experiment can be developed for an undergraduate course that demonstrates principles of drug dissolution.
Dissolutions Role in Drug Development
Alter Hall Poster Session 2 - 2nd floor
The purpose of this research is to understand the process of drug dissolution. Drug dissolution is important since the rate and completeness of the dissolution effect how and if a drug will work. Within this experiment, the dissolution rates of different forms of Aspirin were tested using various pH’s and stir rates. Using a UV-Vis spectrophotometer to test the absorbances of the samples over various time intervals, the maximum release of the drug can be found using calibration and dissolution curves. It was found through the research, that pH and stir rate both affected the dissolution rates of immediate release Aspirin tablets. It was also found that the immediate release has a much quicker dissolution rate than the extended release. Ultimately, from the work done in this research, a lab experiment can be developed for an undergraduate course that demonstrates principles of drug dissolution.
